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Raquel Seruca Selected Research

Cadherins (E-Cadherin)

5/2022Differential Impacts on Tensional Homeostasis of Gastric Cancer Cells Due to Distinct Domain Variants of E-Cadherin.
1/2022Integrin β1 orchestrates the abnormal cell-matrix attachment and invasive behaviour of E-cadherin dysfunctional cells.
8/2021Germline CDH1 G212E Missense Variant: Combining Clinical, In Vitro and In Vivo Strategies to Unravel Disease Burden.
6/2020Hereditary Gastric and Breast Cancer Syndromes Related to CDH1 Germline Mutation: A Multidisciplinary Clinical Review.
1/2020E-cadherin deregulation in breast cancer.
11/2019S100P is a molecular determinant of E-cadherin function in gastric cancer.
1/2019Clinical spectrum and pleiotropic nature of CDH1 germline mutations.
11/2018SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells.
6/2018Dependence of Tensional Homeostasis on Cell Type and on Cell-Cell Interactions.
1/2018Hereditary lobular breast cancer with an emphasis on E-cadherin genetic defect.
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Raquel Seruca Research Topics

Disease

56Neoplasms (Cancer)
05/2022 - 12/2002
55Stomach Neoplasms (Stomach Cancer)
05/2022 - 05/2002
28Carcinoma (Carcinomatosis)
01/2022 - 10/2002
14Breast Neoplasms (Breast Cancer)
06/2020 - 07/2010
13Colorectal Neoplasms (Colorectal Cancer)
10/2015 - 10/2004
12Carcinogenesis
01/2022 - 01/2003
8Infections
01/2020 - 05/2009
7Neoplasm Metastasis (Metastasis)
08/2021 - 10/2005
6Microsatellite Instability
04/2012 - 05/2003
3Adenocarcinoma
06/2018 - 11/2012
3Hereditary Nonpolyposis Colorectal Neoplasms (Hereditary Nonpolyposis Colorectal Cancer)
08/2015 - 12/2002
3Colonic Neoplasms (Colon Cancer)
06/2015 - 12/2002
2Cleft Lip (Harelip)
11/2015 - 01/2013
2Gastrointestinal Neoplasms (Gastrointestinal Cancer)
02/2015 - 01/2010
2Metaplasia
05/2012 - 11/2010
2Inborn Genetic Diseases (Disease, Hereditary)
01/2011 - 05/2004
1Cleft Palate (Palate, Cleft)
11/2015
1Bile Duct Neoplasms (Bile Duct Cancer)
02/2015
1Melanoma (Melanoma, Malignant)
04/2013
1Intestinal Pseudo-Obstruction (Intestinal Pseudoobstruction)
01/2013
1Squamous Cell Neoplasms (Squamous Cell Cancer)
11/2012
1Polyps
11/2010
1Chromosomal Instability (Chromosome Stability)
08/2010

Drug/Important Bio-Agent (IBA)

67Cadherins (E-Cadherin)IBA
05/2022 - 05/2002
15Proteins (Proteins, Gene)FDA Link
01/2022 - 01/2003
9Biomarkers (Surrogate Marker)IBA
01/2022 - 11/2008
7DNA (Deoxyribonucleic Acid)IBA
10/2013 - 10/2002
5Phosphotransferases (Kinase)IBA
01/2020 - 06/2005
5Polysaccharides (Glycans)IBA
10/2016 - 07/2009
5Calcibiotic Root Canal SealerIBA
08/2015 - 10/2004
5Biological ProductsIBA
03/2013 - 09/2007
4Protein Isoforms (Isoforms)IBA
10/2015 - 11/2010
3IntegrinsIBA
01/2022 - 11/2013
3Metalloproteases (Metalloproteinases)IBA
06/2015 - 01/2011
3ErbB Receptors (EGF Receptor)IBA
10/2013 - 01/2008
3Mitochondrial DNA (mtDNA)IBA
10/2013 - 05/2009
3Cell Adhesion MoleculesIBA
03/2013 - 01/2011
3Transcription Factors (Transcription Factor)IBA
01/2013 - 09/2008
3EnzymesIBA
05/2010 - 05/2003
3beta CateninIBA
10/2009 - 01/2003
2CollagenIBA
01/2022 - 08/2003
2Bacterial Proteins (Bacterial Protein)IBA
05/2014 - 01/2013
2AzurinIBA
05/2014 - 01/2013
2Transforming Growth Factor beta (TGF-beta)IBA
03/2014 - 05/2003
2RNA (Ribonucleic Acid)IBA
03/2013 - 03/2010
2Indicators and Reagents (Reagents)IBA
01/2013 - 01/2011
2Messenger RNA (mRNA)IBA
11/2010 - 09/2008
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2008 - 08/2003
2InterleukinsIBA
02/2008 - 08/2003
1VitronectinIBA
05/2022
1Fibronectins (Fibronectin)IBA
05/2022
1alpha2 Subunit Collagen Type IIBA
01/2022
1Tyrosine (L-Tyrosine)FDA Link
01/2020
1tyrosine receptor (receptor, tyrosine)IBA
01/2020
1Small Interfering RNA (siRNA)IBA
01/2020
1src-Family KinasesIBA
11/2018
1Dasatinib (BMS 354825)FDA Link
11/2018
1Protein Sorting Signals (Signal Peptide)IBA
01/2018
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
10/2016
1PlasticsIBA
01/2016
1HydrogelsIBA
01/2016
1Biocompatible Materials (Biomaterials)IBA
01/2016
1Laminin (Merosin)IBA
10/2015
1Transforming Growth Factor-beta Type II ReceptorIBA
08/2015
1Conditioned Culture MediaIBA
06/2015
1Matrix Metalloproteinase InhibitorsIBA
06/2015
1Estrogen ReceptorsIBA
12/2014
1Cdh1 ProteinsIBA
12/2014
1alpha Catenin (alpha E-Catenin)IBA
12/2014
1CholesterolIBA
05/2014
1Histone Deacetylase InhibitorsIBA
10/2013
1GlycosyltransferasesIBA
03/2013
1N-AcetylglucosaminyltransferasesIBA
03/2013
1Insulin (Novolin)FDA Link
01/2013
1CCAAT-Enhancer-Binding ProteinsIBA
01/2013
1Matrix Metalloproteinases (MMPs)IBA
01/2013
1Insulin-Like Growth Factor I (IGF-1)IBA
01/2013
1MicroRNAs (MicroRNA)IBA
09/2012
1Aldehyde Dehydrogenase 1 FamilyIBA
05/2012
1CytokinesIBA
05/2012
1Phenobarbital (Luminal)FDA Link
05/2012
1Glucose (Dextrose)FDA LinkGeneric
03/2012
1docosahexaenoylascorbic acid (DHA-As)IBA
01/2012
1Mitogen-Activated Protein KinasesIBA
02/2011
1Growth Factor ReceptorsIBA
02/2011
13' Untranslated Regions (3' UTR)IBA
02/2011
1Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA
02/2011
1Monoclonal AntibodiesIBA
01/2011
1O-(6)-methylguanineIBA
11/2010
1MethyltransferasesIBA
11/2010
1CCAAT-Enhancer-Binding Protein-alphaIBA
08/2010
1CCAAT-Enhancer-Binding Protein-betaIBA
07/2010
1ChromatinIBA
07/2010
1Fulvestrant (Faslodex)FDA Link
07/2010

Therapy/Procedure

15Therapeutics
01/2020 - 09/2008
3Gastrectomy
01/2020 - 06/2004
3Drug Therapy (Chemotherapy)
10/2013 - 12/2002
2Traction
01/2022 - 06/2018
2Radiotherapy
01/2016 - 01/2016
1Chemoradiotherapy
11/2012